Cardiac arrest and therapeutic hypothermia interaction with isoform- specific cytochrome P450 drug metabolism
نویسندگان
چکیده
Department of Pharmaceutical Sciences (J.Z., S.M.P.) and Department of Pharmacy and Therapeutics (P.E.E.), School of Pharmacy, University of Pittsburgh, Pittsburgh, PA; Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine and Indiana CTSI, Indianapolis, IN (R.R.B.); and Department of Critical Care Medicine, Department of Pediatrics, Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, PA (P.M.K.) DMD #40642 DMD Fast Forward. Published on August 25, 2011 as doi:10.1124/dmd.111.040642
منابع مشابه
Cardiac arrest and therapeutic hypothermia decrease isoform-specific cytochrome P450 drug metabolism.
Mild therapeutic hypothermia is emerging clinically as a neuroprotection therapy for individuals experiencing cardiac arrest (CA); however, its effects combined with disease pathogenesis on drug disposition and response have not been fully elucidated. We determined the activities of four major hepatic-metabolizing enzymes (CYP3A, CYP2C, CYP2D, and CYP2E) during hypothermia after experimental CA...
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OBJECTIVES Therapeutic hypothermia has been shown to decrease neurologic damage in patients experiencing out-of-hospital cardiac arrest. In addition to being treated with hypothermia, critically ill patients are treated with an extensive pharmacotherapeutic regimen. The effects of hypothermia on drug disposition increase the probability for unanticipated toxicity, which could limit its putative...
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